Kollicoat IR®, a new pharmaceutical excipient developed as a coating polymer for instant release tablets, was evaluated as a carrier in solid dispersions of. Kollicoat® IR, a graft copolymer comprised of polyethylene glycol and polyvinyl alcohol (PEG: PVA, ), has been used as an instant release. Cech T., Kolter K. , Influence of plasticizer on the film properties of HPMC and PVA and comparison of the results with the properties of Kollicoat® IR as.
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Download Center Looking for application guides, technical and scientific posters, brochures or technical Information? Poster Evaluating various wet binders to gain lactose based agglomerates applicable for ODT Download. Back to registration form. Cookies help us deliver our services. The hardness of the granules, increased as a function of compression forces in both fluid bed and high shear granulations.
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Country Please choose your country. Thus, minimizing the risks for kolllcoat impurities in the excipients, especially the peroxides, is highly essential, which could otherwise be detrimental to long term stability of pharmaceutical dosages [5 6]. Binders are important ingredients of solid oral dosage formulations SODFs. Likewise, the tablets with povidone K30 bearing the low peroxide e.
Composition of raloxifene tablets. The data from this study demonstrates that PEG-PVA, lacking the inherent residual peroxides as shown in Table 4, curtails the oxidative degradation of raloxifene in the tablets.
Therefore, the efforts continue to identify the appropriate excipients lacking peroxides, or having significantly low peroxides to alleviate the oxidative degradation. The aim of this study kollicoaf to investigate the peroxide free instant release polymer in the instant release matrix tablet and examine the oxidative degradation of raloxifene when used as a wet binder.
The data also demonstrate that the fluid bed granules were highly compressible as compared to those prepared by high shear granulation due to high porosity. Visit our Download Center. These impurities may lead to undesired reactions and alter the efficacy of dosages with possibly adverse effects . These peroxides not only limited to binders and disintegrants such as povidone and crospovidone but to other ingredients such as fillers, lubricants and surfactants, can also cause oxidative degradation of sensitive drugs.
Such processing steps can lead to elevated impurity levels. Granule properties such as particle size and compression profile were evaluated, and compared with kolliclat and HMPC granules. Please provide a valid registered E-Mail ID.
This study also provides an understanding on controlling the degradation of raloxifene and other drugs alike highly sensitive to peroxides by selecting the appropriate binders or excipients lacking residual peroxides. Due to its low viscosity values in aqueous solutions, easy processing in a vast ig parameter range is assured. The oxidative degradation of highly sensitive drug as raloxifene and others alike in wet granulation can be minimized during the formulation process by use of PEG-PVA.
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Please retry again later. Binders and their peroxide levels in raloxifene tablets. Minimizing the Risks for Oxidative Degradation of Drugs.
In a subsequent investigation, Yarkala et al. Our data demonstrates that the PEG-PVA as a peroxide-free binder can withstand the robust processing conditions and can minimize the risk of oxidative degradation as evident from the data kllicoat Table 5. In the ko,licoat shear mixing, the granules however were densely packed, less porous, and hence were less compressible.
Controlling the residual peroxides is therefore critical to improve long term stability and to maintain the quality of pharmaceutical dosage forms, and the research continues to find the optimal solutions. Looking for application guides, technical and scientific posters, brochures or technical Information? This water-soluble film-forming agent is ideal for manufacturing instant-release coatings for solid dosage forms — and for applications such as bindingpore forming and drug layering.
With increasing amounts of peroxides spiked with hydrogen peroxide the formation of N-oxide increased causing a significant loss inpotency of drug . Oxidative degradation of raloxifene. Please check your mailbox for kolicoat information. kolpicoat
Kollicoat® IR: Minimizing the Risks for Oxidative Degradation of Drugs
Your personal data might be passed on to affiliated companies or third parties. HelloYou are logged in with access to additional information. As wet binderit combines powerful binding with no peroxides at all.
Oxidative degradation of raloxifene may lead to adverse reactions . Edmond, OK Tel: The oxidative degradation of raloxifene to N-oxide is shown in Figure 3. Brochure Ensuring the precision you need — every time: You will find the unsubscribe link at the end of each newsletter you receive.