diltiazem, enalapril, phenytoin, fluconazole, haloperidol, itraconazole, macrolides, nifedipine, quinidine, rapamycin, simvastatin, theophylline, and verapamil. Haloperidol adalah obat yang dikategorikan ke dalam agen antipsikotik, antidiskinetik, Efek samping haloperidol berbeda pada berbagai tingkatan usia . efek. Pada pasien skizofrenia penurunan konsentrasi haloperidol 70 % sehingga efek antipsikosis menurun. Litium dapat meningkatkan efek samping peningkatan.

Author: Shami Vudogore
Country: United Arab Emirates
Language: English (Spanish)
Genre: Personal Growth
Published (Last): 27 June 2015
Pages: 241
PDF File Size: 10.6 Mb
ePub File Size: 16.87 Mb
ISBN: 419-5-45707-243-3
Downloads: 9828
Price: Free* [*Free Regsitration Required]
Uploader: Tajora

May be taken with or without food. Therefore, rifampin can increase the metabolism of numerous drugs that are partially or completely metabolized by CYP when these drugs are administered concomitantly with rifampin.

In patients with tuberculosisinduced lung injury, the growth of the bacilli that are phagocytosed by macrophages is inhibited by the acid environment within the phagolysosomes. Tuberculosis; Drug interactions; Antibiotics, antitubercular; Pharmacologic actions; Drug toxicity; Drug-induced liver injury.

Risk factors haloperidoo sideeffects of isoniazid, rifampin and pyrazinamide in patients hospitalized for pulmonary tuberculosis. The management of situations that are more severe which are, fortunately, uncommon is generally the responsibility of referral centers and experienced professionals with knowledge of the therapeutic alternatives available.

The serum half-life of ethambutol is h, and it can be as long as etek h in patients with severe kidney failure. Twenty isoniazidassociated deaths in one state.

Pyrazinamide is a hepatotoxic drug, the effect of which is more evident in individuals with liver disease. Those levels normalize as the treatment continues. Update on rifampin and rifabutin drug interactions. Adjustments to the doses of isoniazid are not required in patients with kidney failure or in those on hemodialysis.

Interleukininduced SB secretion is inhibited by haloperidol and risperidone Documents. The risk of polyneuritis increases in the presence of associated conditions, such as advanced age, diabetes mellitus, alcoholism, nutritional deficiency, slow acetylator phenotype, HIV infection, kidney failure, pregnancy, and breastfeeding. In patients with cholestasis, clinical manifestations occur earlier due to sensitization mechanisms that are evidenced through laboratory testing by an increase in bilirubin and alkaline phosphatase levels.


Ethionamide can exacerbate the sampinng effects of ethambutol. Antituberculosis drug-induced cholestasis can be accompanied by early clinical manifestations, such as increased bilirubin levels and increased alkaline phosphatase levels, the prognosis of the latter being better than that of the former.

Perbandingan Risperidone Dengan Haloperidol

hxloperidol Because rifampin is metabolized in the liver, the drug can be used at full doses in patients with kidney failure. Pyrazinamide is the most hepatotoxic of the drugs cited in the present study. INH induced status epilepticus: Ocular toxicity from ethambutol. When rifampin is used in combination with pyrazinamide, tuberculosis treatment duration can be reduced to six months.

If exanthema occurs, treatment should be discontinued, and the drugs should ssamping subsequently reintroduced, one by one, in order to identify the causative drug.

Perbandingan Risperidone Dengan Haloperidol

Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: Hematological alterations and vasculitis are rare complications of isoniazid administration and occur due to hypersensitivity. Exacerbation of isoniazid induced peripheral neuropathy by pyridoxine. IM Acute psychosis mg hrly or hrly until symptoms are controlled.

In these cases, aminotransferase levels, as well as aamping levels of alkaline phosphatase and bilirubin, should be determined. Maintain a patent airway by using an oropharyngeal airway or endotracheal tube or, in prolonged cases of coma, by tracheostomy.

Antacids containing aluminum hydroxide delay the absorption of rifampin. The possibility of interaction between rifampin and other drugs calls for a thorough history taking that focuses on the drugs currently used by patients. Coma caused by isoniazid poisoning in a patient treated with pyridoxine and hemodialysis. Am J Med Sci. It is supposed that pyrazinamide enters the bacillus passively, is converted into pyrazinoic acid by pyrazinamidase, and reaches high concentrations in the bacterial cytoplasm due to an inefficient efflux system.

Thrombocyto penia, leukopenia, eosinophilia, hemolytic anemia, agranulocytosis, vasculitis, acute interstitial nephritis, and septic shock can occur after rifampin administration. The effect of hemodialysis on isoniazid, rifampin, pyrazinamide, and ethambutol. Mandell, Douglas, and Bennett’s principles and practice of infectious diseases. We also describe the mechanisms by which the interactions among the antituberculosis drugs used in the basic regimen can cause druginduced hepatitis, and we discuss the alternatives in this situation.


Ethambutol is widely distributed throughout the body, with the exception of the CSF in patients without meningitis. In these cases, serology for viral hepatitis should be ordered.

Treatment of tuberculosis in presence of hepatic and renal impairment. Peripheral fiber impairment is less common and manifests as a reduction in the visual field. When retrobulbar neuritis occurs in patients treated with ethambutol, it is generally reversible and depends on the dose and duration of administration.

That were the first rank of side effect in every that antipsycotic. The use of potentially hepatotoxic drugs in patients with liver disease. Rifampin has been used during pregnancy, and no teratogenic effects have haloperisol reported. Risperidon Risperdal Lebih efektifEfek samping neurologik sangat berkurangDapat mengatasi positif dan negatif symptomsII.

Haloperidol: Indication, Dosage, Side Effect, Precaution | Indonesia

This sterilizing activity of pyrazinamide allows the duration of the treatment with the RHZ regimen to be reduced to six months. A large number of interactions can occur between rifampin and other drugs. Haloperidol blocks postsynaptic dopamine D 1 and D 2 receptors in the mesolimbic system and decreases the release of hypothalamic and hypophyseal hormones. Pyrazinamide is the most effective drug in eliminating this population.

Treatment with pyrazinamide can cause photosensitivity dermatitis. However, due to the important role that rifampin plays in tuberculosis treatment regimens, the drug is generally included, with the proviso that the patients be closely monitored through frequent clinical evaluations and laboratory tests see also Drug-induced hepatitis.

Especially when administered in combination with rifampin, isoniazid can reactivate inapparent viral infections in asymptomatic patients and therefore cause the onset of viral hepatitis, usually hepatitis B.