Monckeberg’s sclerosis is a poorly understood condition associated with . Monckeberg’s sclerosis can coexist with atherosclerotic disease. Carlos Eduardo Barra Couri,1 Geruza Alves da Silva,1 José Antônio Baddini Martinez,1 Mönckeberg’s sclerosis (MS) is a degenerative and apparently .. The current concepts of the pathogenesis of Monckeberg-type arteriosclerosis. Mönckeberg sclerosis (MS) is a calcification of the me- dial layer of . ”Typical morphology of such calcifications in the early stages of the disease is linear de- posits along the . arteries in the absence of atherosclerotic plaque. Mayo Clin.

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Since its first description in [ 3 ], MS has only been related to media calcification of small-to-medium-sized arteries, being listed among the primary diseases of the vessels. Its clinical significance and cause are not well understood and its relationship to atherosclerosis and arterioslerosis forms of vascular calcification are the subject of disagreement.

Clinically, the disease manifests by the appearance of arterial type ulcers on the skin of upper and lower extremities.

Arterioscler Thromb Vasc Biol. One large case series reported intimal calcification on histopathology, 15 a feature strongly inconsistent with the conventional definition of Monckeberg’s sclerosis.

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The clinical significance of medial arterial calcification in end-stage renal disease in women. There was the formation of an unusual process of arteriosclerosis, different from the traditional atherosclerosis, which, through an anatomopathological study of the amputation piece, proved to be calcification of Monckeberg’s medial layer.

Outcome and follow-up The patient tolerated the procedure well with no postprocedural complications. Medial calcinosis does not obstruct the lumina of the arteries, and therefore does not lead to symptoms or signs of limb or organ ischemia.

Mönckeberg’s sclerosis – is the artery the only target of calcification?

In other projects Wikimedia Commons. However, the risk of triggering even more tissue calcification secondary to tissue damages discouraged the realization of this procedure. Palpation over the mass showed that it was a procidentia Fig. The aetiology and pathogenesis of Monckeberg’s sclerosis remain unclear. Clinical manifestations of Monckeberg’s sclerosis. In contrast, the second type is defined as a malignant, rapidly progressive form, in which massive and extensive medial calcifications may displace the internal elastica toward the lumen, causing luminal narrowing.


The patient did not present any traditional risk factors associated with atherosclerosis. Circ Res,pp. The authors thank the Department of Pathology of Sikkim Manipal Institute of Medical Sciences for extending them all the necessary help regarding the histopathologic report and the picture, as well as the OBG staff for their support.

Angiography was subsequently performed via the femoral approach. The above suggests that Monckeberg’s sclerosis could be the manifestation of a vascular compromise mediated by immunological genetic and inflammatory alterations that complement a known disease such as atherosclerosis, since at the vascular level it can occur with calcification of the intima layer and this can be associated with atherosclerotic plaques, which result from the accumulation of modified lipids, proinflammatory cytokines and cell apoptosis, compromising the blood flow.

Differential diagnosis Monckeberg’s sclerosis involving bilateral radial and ulnar arteries. Rua Estela,bloco E, conj. By using this site, you agree to the Terms of Use and Privacy Policy. Hydroxyapatite is secreted in vesicles that bleb out from vascular smooth muscle cells or pericytes in the arterial wall.

Radiographic manifestations of Mönckeberg arteriosclerosis in the head and neck region

CS1 German-language sources de Infobox medical condition new. We conclude that Monckeberg’s sclerosis can coexist with coronary artery disease, and can result in unanticipated difficulty in arterial catheterisation. Sleep apnea causes repetitive episodes of hypoxia, hypercapnia and reoxigenation that can lead to a variety of physiological ,onckeberg including pulmonary hypertension and other vascular consequences[ 13 ].

Although a large case series by Chowdhury et arteriosclerlsis 16 showed radial involvement in up to 6.

Monckeberg’s arteriosclerosis – Wikipedia

There were necrotic ulcers in the distal monckebegr of the upper limbs and a holosystolic heart murmur in the aortic area. Comparative histological study of atherosclerotic lesions and microvascular changes in amputated lower limbs of diabetic and non-diabetic patients.


GAS was also responsible for the realization and interpretation of polysomnography. He denied smoking, diabetes mellitus, dyslipidemia, alcoholism or hypertension.

We also thank the patient for giving us a adteriosclerosis consent for publishing his case. This page was last edited on 30 Julyat At admission, the patient was haemodynamically stable. Medial arterial calcification and diabetic neuropathy.

The patient was submitted to exploration of the supragenicular popliteal artery. Recent progress in the treatment of vascular calcification. Published online Apr Calcifications may occur in several locations in the cardiovascular system, including dw intima and media of vessels. It is frequent to found ulcers of arterial type in the upper and lower limbs of distal predominance, so serious that sometimes may require amputation of the extremity to control the symptoms. Histopathology and morphometry of radial artery conduits: There is a broad spectrum of clinical manifestations, all derived from the vascular occlusion which is generated and that includes coronary vessels, the aorta and its branches, with special emphasis on peripheral vessels.

The concomitant atherosclerotic process involving the intima layer of the femoral arteries explained the intermittent claudication and weak pulses presented by this patient. A pressure of 10 cm H 2 O was reached during some short periods of sleep with a very low effect on the frequency of episodes of apnea.

Competing interests The author s declare that they have mockeberg competing interests. Author information Article notes Copyright and License information Disclaimer. Monckeberg’s sclerosis can prevent arterial catheterisation, hampering or even prevent percutaneous intervention. Medical management with statin and antiplatelets was also initiated. Clin J Am Soc Nephrol, 4pp. Frankini II ; Aline S.